Bioinformatics Training Program at NTHRYS is provided under three different modules:
Module I |
||
Theory |
Practical |
Tools |
History |
Biological Databases |
NCBI,MMDB,EMBL,DDBJ,SwissProt |
Origin |
Structure DB |
PDB,CATH,SCOP,InterproScan,Signal Scan |
Scope of Bioinformatics |
Importance of Tools |
N/A |
Origin of Tools |
Sequence DB’s |
Scan,Prosite,Prodom, MotifScan,PFam |
Sequence File Formats |
Types |
Genebank file format,FASTA format,EMBL format,UniprotKB/Swiss-Prot format, PIR/NBRF format |
Module II |
||
Application of Bioinformatics |
Gene Prediction & Functional Analysis |
ORF finder, GeneScan,GeneMark,Webgene |
Sequence Comparison |
EXPASy, EMBOSS |
BLAST,Clustalw,DIALIGN |
Structure File Formats |
Repeat detection |
Repeat Masker, dnadot |
General Introduction to Molecular Biology |
Hydrophobicity |
Protparam |
Restriction Site Mapping |
Restriction site Detection |
Webcutter,NEBCutter |
Visualiztion Software |
System Biology Vs /w |
RasMol,SPDBV,JMol,Cn3D |
Phylogenetic Analysis |
Evolutionary Relationship |
Phylogeny,HHperd, Biology workbench |
Bioinformatics Dogma |
Thermodynamics |
ProTherm |
Minor Project Concerning the concepts learnt |
Theory |
Practical |
Tools |
Module III |
||
Statistical significance of Alignments |
RNA sequence Analysis |
Expasy |
Sequence Databases for similar sequences |
RNA fold Recognition |
MFOLD,PFOLD |
RNA sequence analysis |
Secondary Structure Prediction |
GOR4, ChouFasman, Predator, Phobious, HMMTOP |
RNA structure Prediction |
Abinitio Structure Prediction |
QUARK,Bhageerath |
Submitting Sequence |
To NCBI |
N/A |
Scoring Types |
PAM,BLOSUM |
N/A |
Types of Alignment |
Global & Local |
Grapics Sequences Pairwise BLAST & EMBOSS Aligns |
Module IV |
||
Molecular Phylogeny Prediction |
Molecular evolutionary genetic Analysis |
MEGA5,PHYLIP |
EST and Gene Discovery |
|
dbEST |
Genome Analysis |
|
Genid,FGNEGH,GLIMMER,GRAIL |
Comparative modeling |
Homology Modeling |
MODELER, Swiss Model |
Fold recognition |
Threading |
RAPTOR,3DPSSM,HHPRED |
Model Evaluation |
Structure Refinement |
WHATCHECK,SAVES Server |
Structure Validation |
RMSD plot |
CASP Server |
Module V |
||
Molecular Dynamics |
Molecular Simulation |
GROMACS,HOOMD blue,PYMOL |
Molecular Modeling |
|
CHARM-GUI,Amber |
Primer Desinging |
Three Primer designing tools along with concepts of behind tools |
FastPCR,PRIMER3,Gene Fisher |
Concepts of Biostatistics,biophysicsand biochemistry to help in dealing with databases/tools |
Various tools used to useges, of subject with bioinformatics |
Risk assessment tools,KinCohort software MultAssoc,Genetic Pathway analysis software |
Minor project work in desired topic |
||
Major project in desired topic
Note: Major project as well as Minor project can also done by the student after selected time and respective certification can be issued on the respective date. For example if a MSc first year student joins in this training module he/she can complete the training module and take Training and take training certificate at the time and later come back after few months continue doing the minor project and then collect the certificate and come later at the time of final year academic project time and do the major project and collect the certificate for the same in respective dates and make use of the three certifications for a single fee structure. |
Theory | Practicals | Tools Used |
Module VI |
||
Reconstruction Of Metabolic Pathway |
|
Various pathway construction tools including KEGG |
Pathway Databases |
|
KEGG [all databases ] |
Monte Carlo Simulation |
|
Molecular dynamics tools |
Docking of Small Molecules |
Docking Software |
GOLD, HYPERCHEM, AutoDOCK, Hex, Argus Lab |
Module VII |
||
Energy minimization |
QSAR Studies |
Build QSAR |
Geometry Optimization |
Descriptor Database |
E-Dragon |
Force Fields |
Primer Designing |
Primer3, FastPCR |
Descriptors |
|
|
BioPERL |
BioPERL / PERL programming |
|
Antibody engineering |
Designing and modeling antibodies |
|
HTML concepts |
HTML |
|
Concepts on designing a bioinformatics database |
|
|
Concepts on various biotechnology aspects |
|
|
Major project work in any one of the fields present in NTHRYS Bioinformatics Projects section. |
Module VIII | ||
Topic | Practical Approaches | Software / Tools |
Free Energy Relationships | Hansch method : Linear Free Energy Relationships (physicochemical properties) | QSAR-PC: PAR |
Martin & Kubinyi : Non Linear Free Energy Relationships (physicochemical properties) | ||
Free Wilson mathematical model (structural elements) | ||
Molecular Modeling | Curation | KNIME |
Molecular Descriptors (0D, 1D, 2D, 3D, 4D, 5D, 6D) | Chemistry Development Kit, PADel, RDKit, MOE, PubChem, Chemotypes | |
Modeling Methods
|
ACD/ChemSketch, ACD/3D Viewer, Biomer, MOLEKEL, The Molecular Modelling Toolkit etc., | |
Quantum Mechanical Model |
|
AlgoGen, ProToss, Epik etc., |
Topological Method |
|
ADAPT, CODESSA, MathChem, MDL QSAR, TOPIX, etc., |
Pattern Recognization |
Note
Other Trainings under this field >> Bioinformatics Industrial Training, Bioinformatics Course Finishers Training, Bioinformatics Job Oriented Training, & Bioinformatics Research Training
Fee details in Rs per student | |||||||||
Basic Training Modules | Advanced Modules | Professional Modules | |||||||
Fee | 5 Days | 10 Days | 20 days | 1 Month | 45 Days | 3 Months | 4 Months | 5 Months | 6 Months |
Modules Covered | Module I | Module I & II | Module I, II & Minor Project | Module I, II & III | Module I, II, III, IV & Minor Project | Module I, II, III, IV, V & Major Project | Module I, II, III, IV, V, Minor + Major Project | Module I, II, III, IV, V, VI, VII, Minor + Major Project | Module I, II, III, IV, V, VI, VII, Minor + Major Project [Out of which 1 will be publication project] |
Individual | 14900 | 19200 | 25100 | 36800 | 45300 | 69000 | 120900 | 150900 | 220900 |
Group 2 - 4 | 12100 | 17600 | 23400 | 35000 | 43300 | 67500 | 118800 | 145200 | 215400 |
Group 5 - 7 | 11000 | 15500 | 22200 | 33900 | 40100 | 65200 | 116400 | 143600 | 214700 |
Group 8 - 10 | 9900 | 14400 | 21100 | 30700 | 38900 | 62900 | 115000 | 140100 | 212100 |
Note: NTHRYS currently operates through three registered entities: NTHRYS BIOTECH LABS (NBL), NTHRYS OPC PVT LTD (NOPC), and NTHRYS Project Greenshield (NPGS).