1. Therapeutics
1.1. Personalized Cancer Immunotherapy
Objective
Develop personalized immunotherapies utilizing patients genetic and immune profiles to target specific cancer mutations, enhancing treatment efficacy and minimizing side effects.
Explanation
Utilize advanced sequencing techniques to identify tumor-specific antigens and design immunotherapies, such as neoantigen vaccines and CAR-T cell therapies, tailored to individual patients.
1.2. Gene Editing for Genetic Disorders
Objective
Refine gene editing techniques (CRISPR-Cas9, base editing) to correct genetic mutations responsible for hereditary diseases, aiming for precise and safe interventions.
Explanation
Investigate novel delivery methods, enhance editing accuracy, and develop effective off-target detection tools to enable therapeutic gene editing with minimal risks.
1.3. Neurodegenerative Disease Modifying Treatments
Objective
Discover disease-modifying therapies for neurodegenerative disorders like Alzheimer s and Parkinson s diseases, targeting underlying pathological processes to slow or halt disease progression.
Explanation
Explore small molecules, antibodies, and gene therapies that target toxic protein aggregates, neuroinflammation, and neuronal degeneration, focusing on disease-specific mechanisms.
1.4. Antibiotic Alternatives
Objective
Identify and develop non-antibiotic strategies to combat bacterial infections, including phage therapy, antimicrobial peptides, and CRISPR-based antimicrobials.
Explanation
Investigate the efficacy, safety, and specificity of alternative antimicrobial agents, emphasizing their potential as supplements or replacements for traditional antibiotics.
1.5. Precision Medicine for Rare Diseases
Objective
Implement precision medicine approaches for rare diseases, utilizing genomics, proteomics, and metabolomics to identify targeted therapies and enhance early diagnosis.
Explanation
Establish comprehensive rare disease databases, conduct multi-omics analyses, and facilitate international collaborations to identify common molecular pathways and therapeutic targets across rare diseases.
2. Diagnostics
2.1. Liquid Biopsy Advancements
Objective
Enhance liquid biopsy technologies for early cancer detection and monitoring, focusing on increased sensitivity, specificity, and broader applicability across cancer types.
Explanation
Investigate circulating tumor DNA, RNA, proteins, and extracellular vesicles to develop multi-marker panels and innovative detection methods, ensuring accurate and non-invasive cancer diagnostics.
2.2. Point-of-Care Diagnostics
Objective
Develop rapid, user-friendly, and affordable point-of-care diagnostic devices for infectious diseases, metabolic disorders, and cancer markers, enabling timely interventions.
Explanation
Innovate microfluidics, biosensors, and lab-on-a-chip technologies, integrating them with AI-powered analysis algorithms for real-time, on-site diagnostics in resource-limited settings.
2.3. AI-driven Diagnostic Tools
Objective
Harness artificial intelligence and machine learning algorithms to analyze complex biological and medical data, improving accuracy, speed, and reliability of disease diagnosis.
Explanation
Train AI models using vast datasets, including genomics, imaging, and clinical records, to enable predictive diagnostics, image recognition, and pattern analysis for various diseases.
2.4. Next-generation Sequencing in Diagnostics
Objective
Utilize advanced sequencing technologies (long-read sequencing, nanopore sequencing) for comprehensive genomic analysis in diagnostics, focusing on structural variants and complex genetic diseases.
Explanation
Optimize sequencing protocols, enhance data analysis pipelines, and standardize variant interpretation, ensuring precise identification of disease-causing genetic variations.
2.5. Biomarker Discovery and Validation
Objective
Discover novel biomarkers for various diseases, validate their clinical relevance, and establish standardized assays for widespread diagnostic use.
Explanation
Employ omics technologies and high-throughput screening methods to identify potential biomarkers, followed by rigorous validation studies in diverse patient cohorts, ensuring reliability and reproducibility.
3. Basic Research
3.1. Unraveling Microbiome Complexity
Objective
Investigate the human microbiome s intricacies, including microbe-host interactions, microbial ecology, and functional genomics, to understand its impact on health and disease.
Explanation
Employ metagenomic, metatranscriptomic, and metabolomic approaches to study microbial communities, exploring their roles in immunity, metabolism, and disease susceptibility.
3.2. Stem Cell Biology Advancements
Objective
Expand knowledge of stem cell biology, including pluripotency, tissue-specific differentiation, and stem cell niche interactions, for regenerative medicine and disease modeling.
Explanation
Investigate epigenetic regulation, signaling pathways, and microenvironment cues influencing stem cell fate, enabling safer and more efficient stem cell therapies and disease treatments.
3.3. Functional Genomics and CRISPR Screens
Objective
Utilize CRISPR-based functional genomics techniques to comprehensively map gene functions, interactions, and regulatory networks, uncovering novel drug targets and disease mechanisms.
Explanation
Develop large-scale CRISPR libraries, apply high-throughput screening methodologies, and integrate multi-omics data to decipher gene functions in diverse biological contexts, accelerating drug discovery.
3.4. Understanding Cellular Senescence
Objective
Investigate the molecular mechanisms underlying cellular senescence, exploring its roles in aging, tissue regeneration, and age-related diseases.
Explanation
Explore senescence-associated pathways, biomarkers, and senolytic interventions to selectively remove senescent cells, potentially mitigating age-related diseases and promoting healthier aging.
3.5. Functional Neurobiology
Objective
Unravel the complexities of neural circuits, synaptic plasticity, and neurodevelopmental processes, enhancing our understanding of brain function and neurological disorders.
Explanation
Utilize advanced imaging techniques, optogenetics, and single-cell transcriptomics to map neural circuits, decipher synapse dynamics, and investigate neurodevelopmental disorders, paving the way for targeted therapies.
Testimonials
VB. Bhavana View on Google
I have completed my 6 month dissertation in NTHRYS biotech labs. The lab is adequately equipped with wonderful, attentive and receptive staff. It is a boon to the students venturing into research as well as to students who would like to garner lab exposure. I had a pleasant experience at NTHRYS thanks to Balaji S. Rao Sir for his constant support, mettle and knowledge. I would also like to give special regards to Zarin Mam for teaching me the concepts of bioinformatics with great ease and for helping me in every step of the way. I extend my gratitude to Vijaya Mam, and Sindhu Mam for helping me carry out the project smoothly.
Durba C Bhattacharjee View on Google
I have just completed hands on lab trainings at NTHRYS in biotechnology which includes microbiology, molecular and immunology and had gained really very good experience and confidence having good infra structures with the guidance of Sandhya Maam and Balaji Sir.
Recommending to any fresher of biotechnology or microbiology field who wants to be expert before joining to
related industry.
Razia View on Google
Best place to aquire and practice knowledge.you can start from zero but at the end of the internship you can actually get a job that is the kind of experience you get here.The support and encouragement from the faculty side is just unexplainable because they make you feel like family and teach you every bit of the experiment.I strongly recommend NTHRYS Biotech lab to all the students who want to excel in their career.
Srilatha View on Google
Nice place for hands on training
Nandupandu View on Google
Very good place for students to learn all the techniques
Sadnaax View on Google
I apprenticed in molecular biology and animal tissue culture, helped me a lot for my job applications. Sandhya and Balaji sir were very supportive, very helpful and guided me through every step meticulously. Helped me learn from the basics and helped a lot practically. The environment of the lab is very hygienic and friendly. I had a very good experience learning the modules. Would recommend
Shivika Sharma View on Google
I did an internship in NTHRYS under Balaji sir and Sandhya maam. It was a magnificent experience. As I got hands-on experience on practicals and I was also provided with protocols and I learned new techniques too.This intership will help me forge ahead in life. The staff is very supportive and humble with everyone. Both sir and maam helped me with my each and every doubts without hesitation.
Digvijay Singh Guleria View on Google
I went for 2 months for different training programs at NTHRYS Biotech, had a fun learning experience. Everything was hands-on training and well organised protocols. Thank you Balaji sir and Sandhya mam for this life time experience.
Anushka Saxena View on Google
I’m a biotechnology student from Dy patil University mumbai and I recently completed my 6 months dissertation project at Nthrys Biotech Labs in Hyderabad. I had a great experience and I would highly recommend this lab to other students as well .
The first thing that I appreciated about Nthrys Biotech Labs was the friendly and supportive environment. Balaji sir and the staff Ragini and Sandhya ma’am were always willing to help me and they were always patient with my questions.
I also felt like I was part of a team and that I was making a real contribution to the companys research.
I learned a lot during my dissertation at Nthrys Biotech Labs not only academically but also personally . I had the opportunity to work on a variety of projects, which gave me a broad exposure to the field of biotechnology. I also learned a lot about the research process and how to conduct experiments.
In addition to the technical skills that I learned, I also developed my soft skills during my internship. I learned how to communicate effectively, how to work independently, and how to work as part of a team.
Overall, I had a great experience at Nthrys Biotech Labs and I would highly recommend this company to other students.
Once again I would like to render a big thank you to Balaji Sir and Vijayalakshmi ma’am for imbibing with all the knowledge along with helping me publish my research paper as well and its all because of them I scored unbelievably well in my final semester.
Nithin Pariki View on Google
Lab equipment and protocols are good, it gives good hands on experience for freshers.
